Dr. Irfan Pervaiz (Assistant Professor in the Department of Pharmacy, Gujrat Campus) published a research article entitled “Development of Schiff bases from Amikacin: Synthesis, Antibacterial, Anti-urease Activities and Molecular Docking Studies” (Impact Factor 1.169) in “Letters in Drug Design and Discovery” Journal on December 10, 2020.
The published research was completed in collaboration with the researchers from UOL Gujrat Campus, Islamia University of Bahawalpur and University of Veterinary and Animal Sciences.
In this research, imine derivatives of aminoglycoside, Amikacin were synthesized and explored for the activity against a novel target, Helicobacter pylori urease as potential gastroprotective anti-ulcer agents. These compounds were analyzed against HP Urease (PDB: 1E9Z) via different methodologies such as molecular docking combined with invitro techniques: antimicrobial and enzyme inhibition. Antimicrobial resistance has been quoted by WHO as one of the top 10 global public health threats. Schiff bases of Amikacin can thus prove to be viable solution to the problem of antibiotic resistance.
Letters in Drug Design and Discovery is published by Bentham Science, an Emirates based science, technology and medical publishing company with focus on areas such as medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets and structure-activity relationships. It is indexed in Science Citation Index, PubMed/Medline and Scopus.